Endocrine Abstracts

Nuclear receptors regulate biological responses by acting as ligand dependent transcription factors in target cells. Their ability to modulate transcription is mediated by cofactors which are recruited to target genes by binding to receptors. They can either act as coactivators or corepressors and their roles include their ability to remodel chromatin and to recruit the basic transcription machinery. NRIP1 is transcriptional repressor which is recruited to nuclear receptors in...